PUBLICACIONES

2016 -

Crispin JC, Tsokos GC. Cancer immunosurveillance by CD8 T cells. F1000Res. 2020 Feb 3;9:F1000 Faculty Rev-80. doi: 10.12688/f1000research.21150.1. PMID: 32089832; PMCID: PMC7001753.

Meidan E, Li H, Pan W, Kono M, Yu S, Kyttaris VC, Ioannidis C, Rodriguez Rodriguez N, Crispin JC, Apostolidis SA, Lee P, Manis J, Sharabi A, Tsokos MG, Tsokos GC. Serine/threonine phosphatase PP2A is essential for optimal B cell function. JCI Insight. 2020 Mar 12;5(5):e130655. doi: 10.1172/jci.insight.130655. PMID: 32161189; PMCID: PMC7141385

Díaz L, Zambrano E, Flores ME, Contreras M, Crispín JC, Alemán G, Bravo C, Armenta A, Valdés VJ, Tovar A, Gamba G, Barrios-Payán J, Bobadilla NA. Ethical Considerations in Animal Research: The Principle of 3R's. Rev Invest Clin. 2020 May 7;73(5). Epub ahead of print. PMID: 33048918.

Rodríguez-Rodríguez N, Madera-Salcedo IK, Cisneros-Segura JA, García-González HB, Apostolidis SA, Saint-Martin A, Esquivel-Velázquez M, Nguyen T, Romero-Rodríguez DP, Tsokos GC, Alcocer-Varela J, Rosetti F, Crispín JC. Protein phosphatase 2A B55β limits CD8+ T cell lifespan following cytokine withdrawal. J Clin Invest. 2020 Nov 2;130(11):5989-6004. doi: 10.1172/JCI129479. PMID: 32750040; PMCID: PMC7598088.

Rosetti F, de la Cruz A, CrispĂ­n JC. Gene-function studies in systemic lupus erythematosus. Curr Opin Rheumatol. 2019 Mar;31(2):185-192. doi: 10.1097/BOR.0000000000000572. PMID: 30672908.

Madera-Salcedo IK, Sánchez-Hernández BE, Svyryd Y, Esquivel-Velázquez M, Rodríguez-Rodríguez N, Trejo-Zambrano MI, García-González HB, Hernández-Molina G, Mutchinick OM, Alcocer-Varela J, Rosetti F, Crispín JC. PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases. JCI Insight. 2019 Jul 23;5(16):e126457. doi: 10.1172/jci.insight.126457. PMID: 31335320; PMCID: PMC6777834.

CrispĂ­n JC, Morel L. Editorial: Mechanisms by Which SLE-Associated Genetic Variants Contribute to SLE Pathogenesis. Front Immunol. 2019 Dec 3;10:2808. doi: 10.3389/fimmu.2019.02808. PMID: 31849982; PMCID: PMC6901671.

Flores-Mendoza G, SansĂłn SP, RodrĂ­guez-Castro S, CrispĂ­n JC, Rosetti F. Mechanisms of Tissue Injury in Lupus Nephritis. Trends Mol Med. 2018 Apr;24(4):364-378. doi: 10.1016/j.molmed.2018.02.003. Epub 2018 Mar 8. PMID: 29526595.

Rosetti F, CrispĂ­n JC. Intrathecal anti-suprabasin antibodies in SLE, a cause of local concern? Clin Immunol. 2018 Aug;193:131-132. doi: 10.1016/j.clim.2017.11.013. Epub 2017 Nov 29. PMID: 29197637.

Yoshida N, Comte D, Mizui M, Otomo K, Rosetti F, Mayadas TN, CrispĂ­n JC, Bradley SJ, Koga T, Kono M, Karampetsou MP, Kyttaris VC, Tenbrock K, Tsokos GC. ICER is requisite for Th17 differentiation. Nat Commun. 2016 Sep 29;7:12993. doi: 10.1038/ncomms12993. PMID: 27680869; PMCID: PMC5056420.

Rodríguez-Rodríguez N, Apostolidis SA, Fitzgerald L, Meehan BS, Corbett AJ, Martín-Villa JM, McCluskey J, Tsokos GC, Crispín JC. Pro-inflammatory self-reactive T cells are found within murine TCR-αβ+ CD4- CD8- PD-1+ cells. Eur J Immunol 2016 Apr 6. doi: 10.1002/eji.201546056. PMID: 27060346

Apostolidis SA, Rodríguez-Rodríguez N, Suárez-Fueyo A, Dioufa N, Ozcan E, Crispín JC, Tsokos MG, Tsokos GC. Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol 2016; 17(5): 556-64. doi: 10.1038/ni.3390. PMID: 26974206

Rosetti F, Mayadas TN. The many faces of Mac-1 in autoimmune disease. Immunol Rev 2016; 269(1): 175-93. doi: 10.1111/imr.12373. PMID: 26683153

2011 - 2015

Rosetti F, Chen Y, Sen M, Thayer E, Azcutia V, Herter JM, Luscinskas FW, Cullere X, Zhu C, Mayadas TN. A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force. Cell Rep 2015 Mar 11. pii: S2211-1247 (15) 00183-7. doi: 10.1016/j.celrep.2015.02.037. PMID: 25772353

Herter JM, Grabie N, Cullere X, Azcutia V, Rosetti F, Bennett P, Herter-Sprie GS, Elyaman W, Luscinskas FW, Lichtman AH, Mayadas TN. AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation. Nat Commun 2015 Dec 18; 6: 10182. doi: 10.1038/ncomms10182. PMID: 26680259

Rodríguez-Rodríguez N, Apostolidis SA, Penaloza-MacMaster P, Martín Villa JM, Barouch DH, Tsokos GC, Crispín JC. Programmed cell death 1 and Helios distinguish TCR-αβ+ double-negative (CD4-CD8-) T cells that derive from self-reactive CD8 T cells. J Immunol 2015; 194(9): 4207-14. doi: 10.4049/jimmunol.1402775. PMID: 25825451

Hedrich CM, Rauen T, Apostolidis SA, Grammatikos AP, Rodriguez Rodriguez N, Ioannidis C, Kyttaris VC, Crispin JC, Tsokos GC. Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling. Proc Natl Acad Sci U S A 2014; 111(37): 13457-62. doi: 10.1073/pnas.1408023111. PMID: 25187566

Koga T, Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, Crispín JC, Tsokos GC. CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance. J Clin Invest 2014; 124(5): 2234-45. doi: 10.1172/JCI73411. PMID: 24667640

Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, Apostolidis SA, Kyttaris VC, Tsokos GC. cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells. J Biol Chem 2014; 289(4): 2361-70. doi: 10.1074/jbc.M113.523605. PMID: 24297179

CrispĂ­n JC, Hedrich CM, Tsokos GC. Gene-function studies in systemic lupus erythematosus. Nat Rev Rheumatol 2013; 9(8): 476-84. doi: 10.1038/nrrheum.2013.78. PMID: 23732569

Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN. Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-β autocrine signaling to promote monocyte recruitment. Immunity 2013; 38(5): 1025-37. doi: 10.1016/j.immuni.2013.01.012. PMID: 23623383

Hedrich CM, Rauen T, Crispin JC, Koga T, Ioannidis C, Zajdel M, Kyttaris VC, Tsokos GC. cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease. J Biol Chem 2013; 288(44): 31880-7. doi: 10.1074/jbc.M113.508655. PMID: 24047902

Ichinose K, Zhang Z, Koga T, Juang YT, Kis-TĂłth K, Sharpe AH, Kuchroo V, CrispĂ­n JC, Tsokos GC. Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice. Arthritis Rheum 2013; 65(3): 764-9. doi: 10.1002/art.37790. PMID: 23203389

CrispĂ­n JC. A TWEAK in lupus nephritis. Clin Immunol 2012; 145(2): 139-40. doi: 10.1016/j.clim.2012.09.002. PMID: 23022655

Crispín JC, Vargas-Rojas MI, Monsiváis-Urenda A, Alcocer-Varela J. Phenotype and function of dendritic cells of patients with systemic lupus erythematosus. Clin Immunol 2012; 143(1): 45-50. doi: 10.1016/j.clim.2011.12.004. PMID:22239954

Rosetti F, Tsuboi N, Chen K, Nishi H, Ernandez T, Sethi S, Croce K, Stavrakis G, Alcocer-Varela J, GĂłmez-Martin D, van Rooijen N, Kyttaris VC, Lichtman AH, Tsokos GC, Mayadas TN. Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency. J Immunol 2012; 189(7): 3714-23. PMID: 22933624

CrispĂ­n JC, Apostolidis SA, Rosetti F, Keszei M, Wang N, Terhorst C, Mayadas TN, Tsokos GC. Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism. J Immunol 2012; 188(8): 3567-71. doi: 10.4049/jimmunol.1200143. PMID: 22422882

Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Apostolidis SA, Lo MS, Kyttaris VC, Tsokos GC. cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus. Proc Natl Acad Sci U S A 2012; 109(41): 16606-11. doi: 10.1073/pnas.1210129109. PMID: 23019580

Koga T, Ichinose K, Mizui M, CrispĂ­n JC, Tsokos GC. Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus. J Immunol 2012; 189(7): 3490-6. PMID: 22942433

Apostolidis SA, CrispĂ­n JC, Tsokos GC. IL-17-producing T cells in lupus nephritis. Lupus 2011; 20(2): 120-4. doi: 10.1177/0961203310389100. PMID: 21303828

CrispĂ­n JC. Regulatory T cells as modulators of B cell antibody production. Clin Immunol 2011; 140(3): 216-7. doi: 10.1016/j.clim.2011.05.006. PMID: 21652014

Crispín JC, Apostolidis SA, Finnell MI, Tsokos GC. Induction of PP2A Bβ, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus. Proc Natl Acad Sci U S A 2011; 108(30): 12443-8. doi: 10.1073/pnas.1103915108. PMID: 21746932

Ichinose K, Juang YT, CrispĂ­n JC, Kis-Toth K, Tsokos GC. Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV. Arthritis Rheum 2011; 63(2): 523-9. doi: 10.1002/art.30085. PMID: 20954187

2006 - 2010

CrispĂ­n JC, Liossis SN, Kis-Toth K, Lieberman LA, Kyttaris VC, Juang YT, Tsokos GC. Pathogenesis of human systemic lupus erythematosus: recent advances. Trends Mol Med 2010; 16(2): 47-57. doi: 10.1016/j.molmed.2009.12.005. PMID: 20138006

CrispĂ­n JC, Keenan BT, Finnell MD, Bermas BL, Schur P, Massarotti E, Karlson EW, Fitzgerald LM, Ergin S, Kyttaris VC, Tsokos GC, Costenbader KH. Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity. Arthritis Rheum 2010; 62(5): 1431-7. doi: 10.1002/art.27385. PMID: 20213807

CrispĂ­n JC, Kyttaris VC, Terhorst C, Tsokos GC. T cells as therapeutic targets in SLE. Nat Rev Rheumatol 2010; 6(6): 317-25. doi: 10.1038/nrrheum.2010.60. PMID: 20458333

Mayadas TN, Rosetti F, Ernandez T, Sethi S. Neutrophils: game changers in glomerulonephritis? Trends Mol Med 2010; 16(8): 368-78. doi: 10.1016/j.molmed.2010.06.002. PMID: 20667782

CrispĂ­n JC, Tsokos GC. Interleukin-17-producing T cells in lupus. Curr Opin Rheumatol 2010; 22(5): 499-503. doi: 10.1097/BOR.0b013e32833c62b0. PMID: 20592603

Valdés-Ferrer SI, Crispín JC, Belaunzarán PF, Cantú-Brito CG, Sierra-Madero J, Alcocer-Varela J. Acetylcholine-esterase inhibitor pyridostigmine decreases T cell overactivation in patients infected by HIV. AIDS Res Hum Retroviruses 2009; 25(8): 749-55. doi: 10.1089/aid.2008.0257. PMID: 19645607

CrispĂ­n JC, Tsokos GC. Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype. J Immunol 2009; 183(7): 4675-81. doi: 10.4049/jimmunol.0901533. PMID: 19734235

Nalbandian A, CrispĂ­n JC, Tsokos GC. Interleukin-17 and systemic lupus erythematosus: current concepts. Clin Exp Immunol 2009; 157(2): 209-15. doi: 10.1111/j.1365-2249.2009.03944.x. PMID: 19604260

Edgerton C, CrispĂ­n JC, Moratz CM, Bettelli E, Oukka M, Simovic M, Zacharia A, Egan R, Chen J, Dalle Lucca JJ, Juang YT, Tsokos GC. IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. Clin Immunol 2009; 130(3): 313-21. doi: 10.1016/j.clim.2008.09.019. PMID: 19058762

CrispĂ­n JC, Tsokos GC. Transcriptional regulation of IL-2 in health and autoimmunity. Autoimmun Rev 2009; 8(3): 190-5. doi: 10.1016/j.autrev.2008.07.042. PMID: 18723131

CrispĂ­n JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT, Tsokos GC. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol 2008; 181(12): 8761-6. PMID: 19050297

Vargas-Rojas MI, CrispĂ­n JC, Richaud-Patin Y, Alcocer-Varela J. Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance. Lupus 2008; 17(4): 289-94. doi: 10.1177/0961203307088307. PMID: 18413409

Kopcow HD, Rosetti F, Leung Y, Allan DS, Kutok JL, Strominger JL. T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1. Proc Natl Acad Sci U S A 2008; 105(47): 18472-7. doi: 10.1073/pnas.0809233105. PMID: 19011096

Cohen RA, Bayliss G, CrispĂ­n JC, Kane-Wanger GF, Van Beek CA, Kyttaris VC, Avalos I, Yu CY, Tsokos GC, Stillman IE. T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. Clin Immunol 2008; 128(1): 1-7. doi: 10.1016/j.clim.2008.04.004. PMID: 18565470

CrispĂ­n JC, Kyttaris VC, Juang YT, Tsokos GC. How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype. Trends Immunol 2008; 29(3): 110-5. doi: 10.1016/j.it.2007.12.003. PMID: 18249583

CrispĂ­n JC, Kyttaris V, Juang YT, Tsokos GC. Systemic lupus erythematosus: new molecular targets. Ann Rheum Dis 2007; 66 Suppl 3: iii65-9. PMID: 17934100

CrispĂ­n JC, Alcocer-Varela J. The role myeloid dendritic cells play in the pathogenesis of systemic lupus erythematosus. Autoimmun Rev 2007; 6(7): 450-6. PMID: 17643932

Hernández-Molina G, Reyes E, Crispín JC. ANCA associated glomerulonephritis in a patient with mixed connective tissue disease. Ann Rheum Dis. 2006 Mar;65(3):410-1. doi: 10.1136/ard.2005.039834. PMID: 16474034; PMCID: PMC1798067.

Martínez-Baños D, Crispín JC, Lazo-Langner A, Sánchez-Guerrero J. Moderate and severe neutropenia in patients with systemic lupus erythematosus. Rheumatology 2006; 45(8): 994-8. PMID: 16484291

2001 - 2005

Crispín JC, Martínez-Baños D, Alcocer-Varela J. Adult-onset Still disease as the cause of fever of unknown origin. Medicine 2005; 84(6): 331-7. PMID: 16267408

DĂ­az-Alderete A, CrispĂ­n JC, Vargas-Rojas MI, Alcocer-Varela J. IL-10 production in B cells is confined to CD154+ cells in patients with systemic lupus erythematosus. J Autoimmun 2004; 23(4): 379-83. PMID: 15571932

CrispĂ­n JC, Vargas MI, Alcocer-Varela J. Immunoregulatory T cells in autoimmunity. Autoimmun Rev 2004; 3(2): 45-51. PMID: 15003187

CrispĂ­n JC, MartĂ­nez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 2003; 21(3): 273-6. PMID: 14599852

CrispĂ­n JC, Alcocer-Varela J. Rheumatologic manifestations of diabetes mellitus. Am J Med 2003; 114(9): 753-7. PMID: 12829202

CrispĂ­n JC, Alcocer-Varela J, de Pablo P, MartĂ­nez A, Richaud-Patin Y, AlarcĂłn-Segovia D. Immunoregulatory defects in patients with systemic lupus erythematosus in clinical remission. Lupus 2003; 12(5): 386-93. PMID: 12765302

- 2000

CrispĂ­n JC, MartĂ­nez A, de Pablo P, Velasquillo C, Alcocer-Varela J. Participation of the CD69 antigen in the T-cell activation process of patients with systemic lupus erythematosus. Scand J Immunol 1998; 48(2): 196-200. PMID: 9716112

Cohen RA, Bayliss G, CrispĂ­n JC, Kane-Wanger GF, Van Beek CA, Kyttaris VC, Avalos I, Yu CY, Tsokos GC, Stillman IE. T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. Clin Immunol 2008; 128(1): 1-7.