PUBLICACIONES
2016 -
Crispin JC,
Tsokos GC. Cancer immunosurveillance by CD8 T cells. F1000Res. 2020 Feb
3;9:F1000 Faculty Rev-80. doi: 10.12688/f1000research.21150.1. PMID: 32089832;
PMCID: PMC7001753.
Meidan E, Li
H, Pan W, Kono M, Yu S, Kyttaris VC, Ioannidis C, Rodriguez Rodriguez N,
Crispin JC, Apostolidis SA, Lee P, Manis J, Sharabi A, Tsokos MG, Tsokos GC.
Serine/threonine phosphatase PP2A is essential for optimal B cell function. JCI
Insight. 2020 Mar 12;5(5):e130655. doi: 10.1172/jci.insight.130655. PMID:
32161189; PMCID: PMC7141385
DĂaz L,
Zambrano E, Flores ME, Contreras M, CrispĂn JC, Alemán G, Bravo C, Armenta A,
Valdés VJ, Tovar A, Gamba G, Barrios-Payán J, Bobadilla NA. Ethical
Considerations in Animal Research: The Principle of 3R's. Rev Invest Clin. 2020
May 7;73(5). Epub ahead of print. PMID: 33048918.
RodrĂguez-RodrĂguez
N, Madera-Salcedo IK, Cisneros-Segura JA, GarcĂa-González HB, Apostolidis SA,
Saint-Martin A, Esquivel-Velázquez M, Nguyen T, Romero-RodrĂguez DP, Tsokos GC,
Alcocer-Varela J, Rosetti F, CrispĂn JC. Protein phosphatase 2A B55β limits
CD8+ T cell lifespan following cytokine withdrawal. J Clin Invest. 2020 Nov
2;130(11):5989-6004. doi: 10.1172/JCI129479. PMID: 32750040; PMCID: PMC7598088.
Rosetti F,
de la Cruz A, CrispĂn JC. Gene-function studies in systemic lupus
erythematosus. Curr Opin Rheumatol. 2019 Mar;31(2):185-192. doi:
10.1097/BOR.0000000000000572. PMID: 30672908.
Madera-Salcedo
IK, Sánchez-Hernández BE, Svyryd Y, Esquivel-Velázquez M, RodrĂguez-RodrĂguez
N, Trejo-Zambrano MI, GarcĂa-González HB, Hernández-Molina G, Mutchinick OM,
Alcocer-Varela J, Rosetti F, CrispĂn JC. PPP2R2B hypermethylation causes
acquired apoptosis deficiency in systemic autoimmune diseases. JCI Insight.
2019 Jul 23;5(16):e126457. doi: 10.1172/jci.insight.126457. PMID: 31335320;
PMCID: PMC6777834.
CrispĂn JC,
Morel L. Editorial: Mechanisms by Which SLE-Associated Genetic Variants
Contribute to SLE Pathogenesis. Front Immunol. 2019 Dec 3;10:2808. doi:
10.3389/fimmu.2019.02808. PMID: 31849982; PMCID: PMC6901671.
Flores-Mendoza
G, SansĂłn SP, RodrĂguez-Castro S, CrispĂn JC, Rosetti F. Mechanisms of Tissue
Injury in Lupus Nephritis. Trends Mol Med. 2018 Apr;24(4):364-378. doi:
10.1016/j.molmed.2018.02.003. Epub 2018 Mar 8. PMID: 29526595.
Rosetti F,
CrispĂn JC. Intrathecal anti-suprabasin antibodies in SLE, a cause of local
concern? Clin Immunol. 2018 Aug;193:131-132. doi: 10.1016/j.clim.2017.11.013.
Epub 2017 Nov 29. PMID: 29197637.
Yoshida N,
Comte D, Mizui M, Otomo K, Rosetti F, Mayadas TN, CrispĂn JC, Bradley SJ, Koga
T, Kono M, Karampetsou MP, Kyttaris VC, Tenbrock K, Tsokos GC. ICER is
requisite for Th17 differentiation. Nat Commun. 2016 Sep 29;7:12993. doi:
10.1038/ncomms12993. PMID: 27680869; PMCID: PMC5056420.
RodrĂguez-RodrĂguez
N, Apostolidis SA, Fitzgerald L, Meehan BS, Corbett AJ, MartĂn-Villa JM,
McCluskey J, Tsokos GC, CrispĂn JC. Pro-inflammatory self-reactive T cells are
found within murine TCR-αβ+ CD4- CD8- PD-1+ cells. Eur J Immunol 2016 Apr 6.
doi: 10.1002/eji.201546056. PMID: 27060346
Apostolidis
SA, RodrĂguez-RodrĂguez N, Suárez-Fueyo A, Dioufa N, Ozcan E, CrispĂn JC,
Tsokos MG, Tsokos GC. Phosphatase PP2A is requisite for the function of
regulatory T cells. Nat Immunol 2016; 17(5): 556-64. doi: 10.1038/ni.3390.
PMID: 26974206
Rosetti F,
Mayadas TN. The many faces of Mac-1 in autoimmune disease. Immunol Rev 2016;
269(1): 175-93. doi: 10.1111/imr.12373. PMID: 26683153
2011 - 2015
Rosetti F,
Chen Y, Sen M, Thayer E, Azcutia V, Herter JM, Luscinskas FW, Cullere X, Zhu C,
Mayadas TN. A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery
and Interaction with Ligands under Force. Cell Rep 2015 Mar 11. pii: S2211-1247
(15) 00183-7. doi: 10.1016/j.celrep.2015.02.037. PMID: 25772353
Herter JM,
Grabie N, Cullere X, Azcutia V, Rosetti F, Bennett P, Herter-Sprie GS, Elyaman
W, Luscinskas FW, Lichtman AH, Mayadas TN. AKAP9 regulates activation-induced
retention of T lymphocytes at sites of inflammation. Nat Commun 2015 Dec 18; 6:
10182. doi: 10.1038/ncomms10182. PMID: 26680259
RodrĂguez-RodrĂguez
N, Apostolidis SA, Penaloza-MacMaster P, MartĂn Villa JM, Barouch DH, Tsokos
GC, CrispĂn JC. Programmed cell death 1 and Helios distinguish TCR-αβ+
double-negative (CD4-CD8-) T cells that derive from self-reactive CD8 T cells.
J Immunol 2015; 194(9): 4207-14. doi: 10.4049/jimmunol.1402775. PMID: 25825451
Hedrich CM,
Rauen T, Apostolidis SA, Grammatikos AP, Rodriguez Rodriguez N, Ioannidis C,
Kyttaris VC, Crispin JC, Tsokos GC. Stat3 promotes IL-10 expression in lupus T
cells through trans-activation and chromatin remodeling. Proc Natl Acad Sci U S
A 2014; 111(37): 13457-62. doi: 10.1073/pnas.1408023111. PMID: 25187566
Koga T,
Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, CrispĂn JC,
Tsokos GC. CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated
Th17 imbalance. J Clin Invest 2014; 124(5): 2234-45. doi: 10.1172/JCI73411.
PMID: 24667640
Hedrich CM,
CrispĂn JC, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, Apostolidis
SA, Kyttaris VC, Tsokos GC. cAMP responsive element modulator (CREM) α mediates
chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells. J
Biol Chem 2014; 289(4): 2361-70. doi: 10.1074/jbc.M113.523605. PMID: 24297179
CrispĂn JC,
Hedrich CM, Tsokos GC. Gene-function studies in systemic lupus erythematosus. Nat
Rev Rheumatol 2013; 9(8): 476-84. doi: 10.1038/nrrheum.2013.78. PMID: 23732569
Venkatesh D,
Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G,
GarcĂa-Cardeña G, Horwitz BH, Mayadas TN. Endothelial TNF receptor 2 induces
IRF1 transcription factor-dependent interferon-β autocrine signaling to promote
monocyte recruitment. Immunity 2013; 38(5): 1025-37. doi:
10.1016/j.immuni.2013.01.012. PMID: 23623383
Hedrich CM,
Rauen T, Crispin JC, Koga T, Ioannidis C, Zajdel M, Kyttaris VC, Tsokos GC.
cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane
glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health
and disease. J Biol Chem 2013; 288(44): 31880-7. doi: 10.1074/jbc.M113.508655.
PMID: 24047902
Ichinose K,
Zhang Z, Koga T, Juang YT, Kis-TĂłth K, Sharpe AH, Kuchroo V, CrispĂn JC, Tsokos
GC. Brief report: increased expression of a short splice variant of CTLA-4 exacerbates
lupus in MRL/lpr mice. Arthritis Rheum 2013; 65(3): 764-9. doi:
10.1002/art.37790. PMID: 23203389
CrispĂn JC.
A TWEAK in lupus nephritis. Clin Immunol 2012; 145(2): 139-40. doi:
10.1016/j.clim.2012.09.002. PMID: 23022655
CrispĂn JC,
Vargas-Rojas MI, Monsiváis-Urenda A, Alcocer-Varela J. Phenotype and function
of dendritic cells of patients with systemic lupus erythematosus. Clin Immunol
2012; 143(1): 45-50. doi: 10.1016/j.clim.2011.12.004. PMID:22239954
Rosetti F,
Tsuboi N, Chen K, Nishi H, Ernandez T, Sethi S, Croce K, Stavrakis G,
Alcocer-Varela J, GĂłmez-Martin D, van Rooijen N, Kyttaris VC, Lichtman AH,
Tsokos GC, Mayadas TN. Human lupus serum induces neutrophil-mediated organ
damage in mice that is enabled by Mac-1 deficiency. J Immunol 2012; 189(7):
3714-23. PMID: 22933624
CrispĂn JC,
Apostolidis SA, Rosetti F, Keszei M, Wang N, Terhorst C, Mayadas TN, Tsokos GC.
Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune
disease through an IL-17-dependent mechanism. J Immunol 2012; 188(8): 3567-71.
doi: 10.4049/jimmunol.1200143. PMID: 22422882
Hedrich CM,
CrispĂn JC, Rauen T, Ioannidis C, Apostolidis SA, Lo MS, Kyttaris VC, Tsokos
GC. cAMP response element modulator α controls IL2 and IL17A expression during
CD4 lineage commitment and subset distribution in lupus. Proc Natl Acad Sci U S
A 2012; 109(41): 16606-11. doi: 10.1073/pnas.1210129109. PMID: 23019580
Koga T,
Ichinose K, Mizui M, CrispĂn JC, Tsokos GC. Calcium/calmodulin-dependent
protein kinase IV suppresses IL-2 production and regulatory T cell activity in
lupus. J Immunol 2012; 189(7): 3490-6. PMID: 22942433
Apostolidis
SA, CrispĂn JC, Tsokos GC. IL-17-producing T cells in lupus nephritis. Lupus
2011; 20(2): 120-4. doi: 10.1177/0961203310389100. PMID: 21303828
CrispĂn JC.
Regulatory T cells as modulators of B cell antibody production. Clin Immunol
2011; 140(3): 216-7. doi: 10.1016/j.clim.2011.05.006. PMID: 21652014
CrispĂn JC,
Apostolidis SA, Finnell MI, Tsokos GC. Induction of PP2A Bβ, a regulator of IL-2
deprivation-induced T-cell apoptosis, is deficient in systemic lupus
erythematosus. Proc Natl Acad Sci U S A 2011; 108(30): 12443-8. doi:
10.1073/pnas.1103915108. PMID: 21746932
Ichinose K,
Juang YT, CrispĂn JC, Kis-Toth K, Tsokos GC. Suppression of autoimmunity and
organ pathology in lupus-prone mice upon inhibition of
calcium/calmodulin-dependent protein kinase type IV. Arthritis Rheum 2011;
63(2): 523-9. doi: 10.1002/art.30085. PMID: 20954187
2006 - 2010
CrispĂn JC,
Liossis SN, Kis-Toth K, Lieberman LA, Kyttaris VC, Juang YT, Tsokos GC.
Pathogenesis of human systemic lupus erythematosus: recent advances. Trends Mol
Med 2010; 16(2): 47-57. doi: 10.1016/j.molmed.2009.12.005. PMID: 20138006
CrispĂn JC,
Keenan BT, Finnell MD, Bermas BL, Schur P, Massarotti E, Karlson EW, Fitzgerald
LM, Ergin S, Kyttaris VC, Tsokos GC, Costenbader KH. Expression of CD44 variant
isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic
lupus erythematosus and is correlated with disease activity. Arthritis Rheum
2010; 62(5): 1431-7. doi: 10.1002/art.27385. PMID: 20213807
CrispĂn JC,
Kyttaris VC, Terhorst C, Tsokos GC. T cells as therapeutic targets in SLE. Nat
Rev Rheumatol 2010; 6(6): 317-25. doi: 10.1038/nrrheum.2010.60. PMID: 20458333
Mayadas TN,
Rosetti F, Ernandez T, Sethi S. Neutrophils: game changers in
glomerulonephritis? Trends Mol Med 2010; 16(8): 368-78. doi: 10.1016/j.molmed.2010.06.002.
PMID: 20667782
CrispĂn JC,
Tsokos GC. Interleukin-17-producing T cells in lupus. Curr Opin Rheumatol 2010;
22(5): 499-503. doi: 10.1097/BOR.0b013e32833c62b0. PMID: 20592603
Valdés-Ferrer
SI, CrispĂn JC, Belaunzarán PF, CantĂş-Brito CG, Sierra-Madero J, Alcocer-Varela
J. Acetylcholine-esterase inhibitor pyridostigmine decreases T cell
overactivation in patients infected by HIV. AIDS Res Hum Retroviruses 2009;
25(8): 749-55. doi: 10.1089/aid.2008.0257. PMID: 19645607
CrispĂn JC,
Tsokos GC. Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells
and display an inflammatory effector phenotype. J Immunol 2009; 183(7):
4675-81. doi: 10.4049/jimmunol.0901533. PMID: 19734235
Nalbandian
A, CrispĂn JC, Tsokos GC. Interleukin-17 and systemic lupus erythematosus:
current concepts. Clin Exp Immunol 2009; 157(2): 209-15. doi:
10.1111/j.1365-2249.2009.03944.x. PMID: 19604260
Edgerton C,
CrispĂn JC, Moratz CM, Bettelli E, Oukka M, Simovic M, Zacharia A, Egan R, Chen
J, Dalle Lucca JJ, Juang YT, Tsokos GC. IL-17 producing CD4+ T cells mediate
accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice.
Clin Immunol 2009; 130(3): 313-21. doi: 10.1016/j.clim.2008.09.019. PMID:
19058762
CrispĂn JC,
Tsokos GC. Transcriptional regulation of IL-2 in health and autoimmunity.
Autoimmun Rev 2009; 8(3): 190-5. doi: 10.1016/j.autrev.2008.07.042. PMID:
18723131
CrispĂn JC,
Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT,
Tsokos GC. Expanded double negative T cells in patients with systemic lupus
erythematosus produce IL-17 and infiltrate the kidneys. J Immunol 2008;
181(12): 8761-6. PMID: 19050297
Vargas-Rojas
MI, CrispĂn JC, Richaud-Patin Y, Alcocer-Varela J. Quantitative and qualitative
normal regulatory T cells are not capable of inducing suppression in SLE
patients due to T-cell resistance. Lupus 2008; 17(4): 289-94. doi:
10.1177/0961203307088307. PMID: 18413409
Kopcow HD,
Rosetti F, Leung Y, Allan DS, Kutok JL, Strominger JL. T cell apoptosis at the
maternal-fetal interface in early human pregnancy, involvement of galectin-1.
Proc Natl Acad Sci U S A 2008; 105(47): 18472-7. doi: 10.1073/pnas.0809233105.
PMID: 19011096
Cohen RA,
Bayliss G, CrispĂn JC, Kane-Wanger GF, Van Beek CA, Kyttaris VC, Avalos I, Yu
CY, Tsokos GC, Stillman IE. T cells and in situ cryoglobulin deposition in the
pathogenesis of lupus nephritis. Clin Immunol 2008; 128(1): 1-7. doi:
10.1016/j.clim.2008.04.004. PMID: 18565470
CrispĂn JC,
Kyttaris VC, Juang YT, Tsokos GC. How signaling and gene transcription
aberrations dictate the systemic lupus erythematosus T cell phenotype. Trends
Immunol 2008; 29(3): 110-5. doi: 10.1016/j.it.2007.12.003. PMID: 18249583
CrispĂn
JC, Kyttaris V,
Juang YT, Tsokos GC. Systemic lupus erythematosus: new molecular targets. Ann
Rheum Dis 2007; 66 Suppl 3: iii65-9. PMID: 17934100
CrispĂn JC,
Alcocer-Varela J. The role myeloid dendritic cells play in the pathogenesis of
systemic lupus erythematosus. Autoimmun Rev 2007; 6(7): 450-6. PMID: 17643932
Hernández-Molina
G, Reyes E, CrispĂn JC. ANCA associated glomerulonephritis in a patient with
mixed connective tissue disease. Ann Rheum Dis. 2006 Mar;65(3):410-1. doi:
10.1136/ard.2005.039834. PMID: 16474034; PMCID: PMC1798067.
MartĂnez-Baños
D, CrispĂn JC, Lazo-Langner A, Sánchez-Guerrero J. Moderate and severe
neutropenia in patients with systemic lupus erythematosus. Rheumatology 2006;
45(8): 994-8. PMID: 16484291
2001 - 2005
CrispĂn JC,
MartĂnez-Baños D, Alcocer-Varela J. Adult-onset Still disease as the cause of
fever of unknown origin. Medicine 2005; 84(6): 331-7. PMID: 16267408
DĂaz-Alderete
A, CrispĂn JC, Vargas-Rojas MI, Alcocer-Varela J. IL-10 production in B cells
is confined to CD154+ cells in patients with systemic lupus erythematosus. J
Autoimmun 2004; 23(4): 379-83. PMID: 15571932
CrispĂn JC,
Vargas MI, Alcocer-Varela J. Immunoregulatory T cells in autoimmunity.
Autoimmun Rev 2004; 3(2): 45-51. PMID: 15003187
CrispĂn JC,
MartĂnez A, Alcocer-Varela J. Quantification of regulatory T cells in patients
with systemic lupus erythematosus. J Autoimmun 2003; 21(3): 273-6. PMID:
14599852
CrispĂn JC,
Alcocer-Varela J. Rheumatologic manifestations of diabetes mellitus. Am J Med
2003; 114(9): 753-7. PMID: 12829202
CrispĂn JC,
Alcocer-Varela J, de Pablo P, MartĂnez A, Richaud-Patin Y, AlarcĂłn-Segovia D.
Immunoregulatory defects in patients with systemic lupus erythematosus in
clinical remission. Lupus 2003; 12(5): 386-93. PMID: 12765302
- 2000
CrispĂn JC,
MartĂnez A, de Pablo P, Velasquillo C, Alcocer-Varela J. Participation of the
CD69 antigen in the T-cell activation process of patients with systemic lupus
erythematosus. Scand J Immunol 1998; 48(2): 196-200. PMID: 9716112
Cohen RA, Bayliss G, CrispĂn JC, Kane-Wanger GF, Van Beek CA, Kyttaris VC, Avalos I, Yu CY, Tsokos GC, Stillman IE. T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. Clin Immunol 2008; 128(1): 1-7.